Osteosclerosis: Differential Diagnosis #7

Osteosclerosis, or general increased density in the skeletal bones, is a relatively rare diagnosis. However, when it occurs, the entities that cause it are important to recognize. One way to recall the various causes for osteosclerosis is the mnemonic Regular Sex Makes Occasional Perversions Much More Pleasurable And Fun (Don't look at me - I didn't make it up):

	Disease	Notes
R - Regular	Renal osteodystrophy
S - Sex	Sickle cell disease
M - Makes	Myelofibrosis
O - Occasional	Osteopetrosis	aka Albers-Schonberg disease present with fractures, splenomegaly
P - Perversions	Pynknodysostosis	aka Toulouse-Latrec syndrome associated with acro-osteolysis and Wormian bones
M - Much	Mastocytosis
M - More	Metastatic carcinoma	Breast, prostate, lymphoma/leukemia
P - Pleasurable	Paget's disease
A - And	Athletes
F - Fun	Fluorosis

Pynknodysostosis
Source: Radiopaedia

Other possible causes include osteopoikilosis, osteopathia striata, hypothyroidism, and melorrheostosis. You can thank Brant & Helms for the mnemonic.